杨永乐
湘湖实验室副研究员湘湖实验室（农业浙江省实验室）副研究员，动物疫病与生物疫苗团队优秀青年。博士毕业于浙江大学动物医学系，荷兰 Utrecht University 访问交流博士。主要研究领域为：冠状病毒的细胞入侵和跨种传播机制；猪重要致病性病毒和新生病毒病原学和致病机理；基于反向遗传和 mRNA 递送技术设计新型病毒疫苗。主持国家自然科学基金、浙江省"尖兵领雁"计划子课题等项目3项，参研多项国家重点研发等项目，获浙江大学优秀博士论文等奖项。在 PLoS Pathogens、Journal of Virology、iMeta 等期刊发表学术论文 30 篇，授权发明专利 7 件。中国畜牧兽医学会高级会员、浙江省免疫学会动物免疫专委会会员。
教育与工作经历
2023/07 – 至今
湘湖实验室，副研究员
2021/07 – 2023/06
浙江大学，生命科学学院，博士后 / 助理研究员
2017/09 – 2021/06
浙江大学，动物科学学院，兽医学博士（交叉学科：高分子科学与工程学）
2019/09 – 2020/06
荷兰 Utrecht University，感染与免疫系，公派联合培养
2016/09 – 2017/06
浙江大学，动物科学学院，预防兽医学硕士（硕博连读）
2012/09 – 2016/06
浙江中医药大学，生命科学学院，生物科学，理学学士
主要发表论文
Engineered VP1 mRNA Vaccine Induces Immunity and Complete Protection Against Feline Calicivirus in Cats
Transboundary and Emerging Diseases, 2026, 2026: 9499266
Meng-Di Zhang#, Zhuo-Fang Xie#, Xin-Hong Li, Wei Huang, Qian-Yu Qian, Hong-Tao Cao, Ji-Wei Liu, Ya-Qing Zhang, Bin Wang, Yu Qin, Fu-Shan Shi, Jian-Bin Tang*, Yao-Wei Huang*, Yong-Le Yang*
A gut microbiota-bile acid axis inhibits the infection of an emerging coronavirus by targeting its cellular receptor aminopeptidase N
iMeta, 2025, 4(5): e70061
Ya-Qing Zhang#, Bin Wang#, Yong-Le Yang#, Jin-Xin Meng#, Meng-Di Zhang, Yi-Ke Li, Bo Dong, Yanan Zhang, Bo-Wen Liu, Dong Yang, Chun-Miao Ji, Yao-Wei Huang*, Shu Jeffrey Zhu*
Functional dissection of the spike glycoprotein S1 subunit and identification of cellular cofactors for regulation of swine acute diarrhea syndrome coronavirus entry
Journal of Virology, 2024, 98(4): e0013924
Yong-Le Yang#, Bin Wang#, Wentao Li#, Hou-Li Cai, Qian-Yu Qian, Yu Qin, Fang-Shu Shi, Berend-Jan Bosch*, Yao-Wei Huang*
The origin and evolution of emerged swine acute diarrhea syndrome coronavirus with zoonotic potential
Journal of Medical Virology, 2023, 95(3): e28672
De Yu#, Zhuang-Yan Zhao#, Yong-Le Yang#, Yu Qin, Dan Pan, Li-Xia Yuan, Yao-Wei Huang*, Bin Wang*
Bile acids promote the caveolae-associated entry of swine acute diarrhea syndrome coronavirus in porcine intestinal enteroids
PLoS Pathogens, 2022, 18(6): e1010620
Qi-Yue Yang#, Yong-Le Yang#, Yi-Xin Tang, Pan Qin, Gan Wang, Jin-Yan Xie, Shu-Xian Chen, Chan Ding, Yao-Wei Huang, Shu Jeffrey Zhu*
First evidence that an emerging mammalian alphacoronavirus is able to infect an avian species
Transboundary and Emerging Diseases, 2022, 69(5): e2006–e2019
Xiao-Qiang Mei#, Pan Qin#, Yong-Le Yang#, Min Liao, Qi-Zhang Liang, Zhuangzhuang Zhao, Fang-Shu Shi, Bin Wang, Yao-Wei Huang*
Swine enteric alphacoronavirus (swine acute diarrhea syndrome coronavirus): An update three years after its discovery
Virus Research, 2020, 285: 198024
Yong-Le Yang, Jia-Qi Yu, Yao-Wei Huang*
Broad Cross-Species Infection of Cultured Cells by Bat HKU2-Related Swine Acute Diarrhea Syndrome Coronavirus and Identification of Its Replication in Murine Dendritic Cells In Vivo Highlight Its Potential for Diverse Interspecies Transmission
Journal of Virology, 2019, 93(24): e01448-01419
Yong-Le Yang#, Pan Qin#, Bin Wang, Yan Liu, Guo-Han Xu, Lei Peng, Jiyong Zhou, Shu Jeffrey Zhu*, Yao-Wei Huang*
Characterization of a novel bat-HKU2-like swine enteric alphacoronavirus (SeACoV) infection in cultured cells and development of a SeACoV infectious clone
Virology, 2019, 536: 110-118
Yong-Le Yang, Qi-Zhang Liang, Shu-Ya Xu, Evgeniia Mazing, Guo-Han Xu, Lei Peng, Pan Qin, Bin Wang, Yao-Wei Huang*
Specific recombinant proteins of porcine epidemic diarrhea virus are immunogenic, revealing their potential use as diagnostic markers
Veterinary Microbiology, 2019, 236: 108387
Xi-Mei Lei, Yong-Le Yang, Yong-Qiang He, Lei Peng, Pengwei Zhao, Shu-Ya Xu, Hongwei Cao, Pengfei Fang, Wenying Qiu, Pan Qin, Bin Wang, Yao-Wei Huang*
Porcine deltacoronavirus engages the transmissible gastroenteritis virus functional receptor porcine aminopeptidase N for infectious cellular entry
Journal of Virology, 2018, 92(12): e00318-00318
Bin Wang#, Yan Liu#, Chun-Miao Ji#, Yong-Le Yang, Qi-Zhang Liang, Pengwei Zhao, Ling-Dong Xu, Xi-Mei Lei, Wen-Ting Luo, Pan Qin, Jiyong Zhou, Yao-Wei Huang*
pPeOp from Omphalia lapidescens Schroet induces cell cycle arrest and inhibits the migration of MC-4 gastric tumor cells
Oncology Letters, 2017, 14(1): 533-540
Yong-Le Yang, Wei-Yao Gong, Fei-Fei Chen, Lu-Chao Chen, Yi-Tao Chen*